The effects of shuxuening injection (Ginkgo bil oba extract for intravenous

Abstract：Objective:To study the effects of shuxuening injection (Ginkgo biloba extract for intravenous injection) on hemorheology and throm bokinesis in vivo of rats.Methods:The hemorheologic study was cond ucted in rat's model with hyper-viscosity(RMHV)and the experiment on thrombokin esis induced by electric stimulation was conducted in rats　in vivo.Re sults:①?After subcutaneous injection of adrenaline,the viscosity of whole blood and pl asma in RMHV were increased at different shears in comparison with nomal rats.② ?After intravenous administration of 0.5ml/kg shuxuening injection,the decrease in whole blood viscosity in RMHV at different shears(1s-1,5s-1,50s -1,100s-1) were 24.3%,21.4%,19.9% and 16.5%(P?.01 for all) resp ectively,the corresponding decrease in plasma viscosity were 17.4%,19.6%,18.2% a nd 16.6%(P?.05 for all) respectively;and no effect on erythrocytic aggregat ion in dex was observed.③?After intravenous administration of 0.75ml/kg shuxuen ing injection,the decrease in whole blood viscocity in RMHV at different shears( 1s-1,5s-1,50s-1,100s-1) were 61.6%,44.6%,24.6% and 26.0% (P?.001 for all) respectively;the corresponding decrease in plasma viscosit y were 42.1%,44.8%,43.5% and 43.8%(P?.001 for all) respeetively,the decreas e in hematocrit was 12.5%(P?.01) and erythrocytic aggregation index decreas ed markedly(P?.001).④?30 minutes after intravenous administration of 0.5 and 0.75ml/kg shuxuening injection,the increase in thrombokinesis time was 68.8% (P?.05) and 113.8%(P?.01) respectively.Conclusion:Intrav enous administration of shuxuening injection can decrease the blood viscosity an d prolong the thrombokinesis time in rats.