Effect of ranitidine bismuth citrate on experimental gastric u lcer
XU Hui
YAO Quan-sheng
ZHOU Guo-lin
Abstract：Objective:To study the effect of ranitidine bismuth cit
rate (RBC) on four kinds of experimental gastric ulcer.Methods :The inh
ibitory effect of RBC on experimental ulcers:including aqueous extra
ct e xcitability ulcer in mice,acetic acid induced ulcer in rats,pylor
ic ligational u lcer in rats,ethanol induced ulcer in rats were observe
d.Results:R BC showed significant protective effect on 4 experimenta
l gastric ulcers.RBC sig nificantly reduced the gastric ulcerogenesi
s,gastric acid secretion,and gastric pepsin activity(in pyloric liga
tion model) in animal models.Ranitidine HCl was a lso effective in trea
tment of gastric ulcer but less poten t than RBC in these models.Conclus
ion:RBC is a suitable agent for treatment of gastric ulcer because it po
ssesses the inhibitory effect of gastric acid secretion of ranitidine
and mucosal protective and pepsin inhibitory effec t of bismuth.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 182-185 )