T2 weighted magnetic resonance imaging,JH1，D，Z-and JP31，D，Z-magnetic resonance spectroscopy in rats with tem poral cortical infarction and the effects of lumbrokinase
GUAN Xing-zhi
Kuang Pei-gen
WU Wei-ping
KUANG Pei-Zi
GAO Yang
GUAN Lin-Chu
LI Li-yun
MAO Xi-An
LIU Mai-li
Abstract：Objective：To investigate the longitudinal changes of edema and substance and energy metabolism after cerebral infarction,
and the e ffects of lumbrokinase.Methods：By means of the animal model of ph otochemically induced temporal cortical infarction and the techn
ology of T2 we ighted magnetic resonance imaging (MRI),JH1，D，Z-and JP31，D，Z-magne tic resonance spectroscopy (MRS).Results：On the 1s
t,3rd,5th and 7 th day after i nfarction,a region of T2 hyperintensity was observed in left temporal neocorte x in infarction group and lumbroki
nase group.The volume and T2 intensity of th e region gradually decreased from the 1st to the 7th day after infarction;the ra tio of NAA/(Cho+Cr) i
n the region in infarction group was significantly lower th an that in the corresponding region in sham-operated group on the 3rd,5th and 7 th day
after infarction respectively (P?.05); Lac appeared in the region in infarction group on the 1st,3rd,5th and 7th day after infarction, and wa
s not observed in the corresponding regio n in sham-operated group at all time points.Compared with sham-operated group, the ratio of βATP/(PME
+PDE) of the whole brain in infarction group was signifi cantly lower on the 1st,3rd and 5th day after infarction respectively (P?.0 5). Lumbro
kinase significantly decreased the volume of the region of T2 hyperi ntensity on the 1st day after infarction (P?.05), significantly increase
d t he ratio of NAA/(Cho+Cr) of the region on the 7th day after infarction (P<0. 05), and significantly increased the ratio of βATP/(PME+PDE) of the w
hole brain on the 1st day after infarction (P?.05).Conclusion：The resu lts indicated that the infracted region had severe edema, increased L
ac and appa rent neuronal dysfunction and death,and energy metabolism of the whole brain de creased after focal infarction, and that lumbroki
nase effectively ameliorated th e edema of infarcts and promoted energy metabolism of the whole brain at the ear ly stage of focal cerebral infa
rction, and decreased the neuronal dysfunction an d death in infarcts at the late stage.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 179-182 )