Study of the safety and efficacy of AEDs plus topiramate in treatment of refractory partial epilepsy
SUN Hong-bin
XU Fei
LIU Jie
YANG You-song
Abstract：Objective:To study the safety and efficacy of AEDs p lus topiramate in treatment of refractory partial epilepsy.Methods :The open,self-controlled clinical trial was conducted in 16 patients with refr actory partial epilepsy.They were treated with topiramate in an initial dose of 25mg/d and then increased by 25mg every week untill a dose of 200mg/d was achiev ed and maintained at that dose.The seizure rate and tolerability were observed b efore and after add-on therapy.Results:After 24 weeks of treatmen t,the seizure rate was decreased by ≥50% in 7 cases(43.8%;including 3 cases of no seizure),2 cases decrease in seizure rate of 26%～49% and by≤25% in 5 cases. In the contrary,the seizure rate was significantly increased in 1 case and faile d to follow up in 1 case after 12 weeks of treatment.Conclusion:Da ta obtain shows that topiramate is a new antiepileptic agent with multiple mecha nism of action,the total effective rate in the add-on therapy is 56.3%(9/16)wit hout severe side effect,with good tolerability in treatment of refratory partial epilepsy.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 133-135 )