Clinical observation of the efficacy of topiramate monotherapy in treatment of 31 cases of epilepsy
XU Chun-ling
PAN Ying-fu
LI Xiu-hua
SUN Di
Abstract：Objective:To observe the efficacy of topiram ate monotherapy in treatment of 31 cases of epilepsy.Methods:31 pa tients were enrolled into the study and the seizure rate and side effects were r ecorded during the study.The targeted dosage was 100mg topiramate(TPM).There wer e 3 periods to reach the goal dosage:the baseline period(4 weeks) to observe th e seizure rate;titrated period (4～8 weeks) to increase dose to the goal dos age; dose maintain period(12 weeks).Results:The total effective rate of this study is 86.6% including significant effective rate of 73.3% and 13.4% of ineffective and pejorative cases.The reduction in seizure rate was more than 75% for all the types of seizures and incidence of side effect was 60% but most of them were mild and tranisient.Conclusion:TPM is an effective and s afe agent for treatment of epilepsy.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 129-131 )