Relationship between therapeutic effect of ris peridone,clozapine,chlorpromazine and pre-and post-treatment changes in glutamate level in patients with schizophrenia
WANG Shao-li
WENG Yong-zhen
HUANG Shu-zhen
HAN Xiao-le
LI Ke-jin
Abstract：Objective:To explore the effect of some antipsychiatri c drugs on serum glutamate level in relation to therapeutic effects.Methods:60 patients were randomized to receive risperidone,clozapine,a nd chlorpromazine in specific dose for 8 weeks and their clinical symptoms were assessed using BPRS(Brief Psychiatric Rating Scale), SANS (Scale for Assessment of Positive Symptom)，SAPS(Scale for Assessment of Positive Symptom) and WCST (W isconsin Card Sorting Test).Serum glutamate content (SGC) was determined before and after treatment and normal serum glutamate conc entration was obtained from 15 healthy volunteers.Results:The post-tr eatment SGC for all drugs was significantly higher than that of pre-treatment e xcept chlorpromazine(P<0.01).The clinical effectiveness was positively corre lated with the difference of SGCs in pre-and post-treatment groups of risperid one and clozapine.Conclusion:Glutamatergic system can be affected by r isperidone and clozapine treatment and it may be related to improvement in psych iatric symptoms.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 102-104 )