The liver-protective and immunomodulative effect of Shahepatide in mice with immune liver injury
GUO Yu
WU Wu-tong
WU Guan-zhong
Abstract：Objectives:To explore the effect of Shahepatide,an a ctive polypeptide extracted from shark liver,on secretion of IFN-γ and TNP-β from human periperal blood mononuclear cells (PBMC)and to explore its liver-pr otective effect in mice with immune liver injury.Methods:Shahepati de was added to PBMC and cultured.The content of IFN-γ and TNF-β in the cult ure supernatant were measured.Mice model of immune liver injury was created by endotoxin attack and their blood AST and ALT level were determined.Resul ts:Shahepatide can induce secretion of IFN-γ from PBMC(P<0.01),inhib it production of TNF-β from PBMC,can significantly reduce the abmomal elevatio n of serum ALT and AST in mice with immune liver injury and obviously reduce the ir pathological liver injury.Conclusions:Shaheptide possesses an e xcellent prospect in treatment of hepatitis B,liver cirrhosis,and chronic hepati tis,as well as in modulation of immunologic functions.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 29-31 )