The role and mechanism of Calcium/calmodulin-dependent protein kinase Ⅱ in cardiovascular diseases
GUAN Jing-yue
SHI Xiao-cui
LU Cong-cong
SONG Guo-yuan
LI Yi-chen
CHEN Xin-yue
MA Fang-fang
Abstract：Calcium/calmodulin-dependent protein kinase Ⅱ(CaMK Ⅱ)is a protein kinase found in cardiac and brain tissues,as well as in various other cell types.It plays a pivotal role in maintaining normal cardiac physiology.This kinase significantly influences cardiovascular homeostasis by regulating processes such as calcium cycling,electrophysiological activity,and gene expression.Recent studies have highlighted a strong association between abnormal CaMK Ⅱactivation and the pathogenesis of various cardiovascular diseases.Several CaMK Ⅱ inhibitors have demonstrated promising therapeutic effects in preliminary clinical studies,providing valuable insights for the development of novel cardiovascular therapies.This review offers a comprehensive analysis of the role and mechanisms of CaMK Ⅱ in cardiovascular diseases,presenting novel insights and directions for research in cardiovascular biology and medicine.
Keywords：Calcium/calmodulin-dependent protein kinase ⅡCardiovascular diseasesHeart FailureArrhythmiaIschemic cardiomyopathy
Publication Date：2026-01-25
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：7( 77-83 )