Analysis of the correlation between uncoupling protein 2 levels and myocardial ischemia-reperfusion injury after cardiopulmonary bypass surgery
LI Chuang
MA Zhen-jie
YANG Jing-yun
PAN Lu-sheng
SHI Jian
RAN Ji-peng
XING Hui-jiao
ZHANG Jing-bo
Abstract：Objective To evaluate the predictive value of uncoupling protein 2(UCP2),creatine kinase-MB(CK-MB),cardiac troponin T(cTnT),and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels for myocardial ischemia-reperfusion injury(MIRI)following cardiopulmonary bypass(CPB)surgery.Methods The study included 300 patients who underwent CPB surgery between January 2022 and December 2024 in Baoding First Central Hospital Cardiovascular Surgery,venous blood samples were collected at 1 h,6 h,12 h,24 h,and 48 h after surgery to measure UCP2,cTnI,CK-MB,and NT-proBNP.According to the occurrence of MIRI within 72 h post-operation(based on the Fourth Universal Definition of Myocardial Infarction),patients were divided into the MIRI group(n=120)and the non-MIRI group(n=180).Clinical outcomes included 30-day major adverse cardiovascular and cerebrovascular events(MACCE)and 90-day left ventricular ejection fraction(LVEF).The predictive efficacy of each indicator was assessed using multivariate Logistic regression analysis and receiver operating characteristic(ROC)curve analysis.Results Levels of UCP2,CK-MB,cTnT,and NT-proBNP were significantly higher in the MIRI group than in the non-MIRI group,with UCP2 showing the earliest change(P<0.05),Starting from 1 hour after surgery,UCP2 in the MIRI group was significantly higher than that in the non MIRI group[(16.1±2.6)ng/ml vs.(12.3±2.3)ng/ml,P<0.05]and persisted until 48 hours[(30.1±2.8)ng/ml vs.(8.8±2.4)ng/ml];CTnT,CK-MB,and NT proBNP showed significant differences after 6 hours.UCP2 had the highest odds ratio(OR=3.390)and demonstrated superior sensitivity(0.970)and specificity(0.953)in predicting MIRI.Follow-up results at 1 month and 3 months postoperatively showed that,patients in the MIRI group had significantly lower LVEF[(52.3±4.5)%vs.(58.2±3.8)%、(53.1±4.2)%vs.(59.0±3.5)%]and 6-minute walk test distances[(355.4±50.1)m vs.(426.8±60.7)m、(380.4±55.1)m vs.(450.7±65.4)m]compared to the non-MIRI group.Conclusion UCP2 is an independent,early,and potent predictor of MIRI following CPB surgery,demonstrating superior sensitivity and specificity compared with conventional biomarkers.It can be utilized for peri-operative risk stratification and to inform antioxidant and mitochondrial protective therapies.
Keywords：Cardiopulmonary bypassMyocardial ischemia-reperfusion injuryUncoupling protein 2Creatine kinase-MBCardiac troponin TN-terminal pro-brain natriuretic peptideEarly prediction
Publication Date：2026-01-25
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：5( 48-52 )