Liwen procedure in hypertrophic obstructive cardiomyopathy:A retrospective cohort study on age stratified efficacy and safety profiles
HU Zhong-hui
XIAO Hong-yan
TAO Liang
Abstract：Objective To compare the efficacy and safety of the Liwen procedure in treating obstructive hypertrophic cardiomyopathy(OHCM)across different age groups,with a specific focus on its safety and effectiveness in elderly patients.Methods This study employed a retrospective cohort analysis involving 108 patients with OHCM who underwent Liwen surgery at Wuhan Asia Heart Hospital from December 2019 to April 2024.Patients were stratified into two groups:those age<70 years(n=88)and those age≥70 years(n=20).Propensity score matching(PSM)was used to control for baseline confounding factors.Short-term efficacy and perioperative safety were compared between the two groups.Results Within-group comparisons demonstrated that the Liwen procedure was significantly effective in both age groups.The resting left ventricular outflow tract gradient(LVOTG)decreased significantly after the procedure(age<70 group:from 78.50 mmHg to 12.00 mmHg;age≥70 group:from 82.00 mmHg to 25.00 mmHg;P<0.05).Interventricular septal thickness(IVST)also decreased significantly[age<70 group:from(2.30±0.48)cm to(1.71±0.26)cm,P<0.001;age≥70 group:from(2.30±0.48)cm to(1.72±0.44)cm,P<0.001].Between-group comparisons after PSM indicated no significant differences in preoperative resting LVOTG or IVST 82.00(75.00,100.00)mmHg vs.78.50(64.50,116.00)mmHg,(2.30±0.48)cm vs.(2.30±0.48)cm,P>0.05].Postoperative resting LVOTG and IVST were also comparable between the two groups[25.00(12.00,49.50)mmHg vs.12.00(8.00,37.75)mmHg,IVST:(1.72±0.44)cm vs.(1.71±0.26)cm,P>0.05].There were no significant differences in ICU length of stay or complication rates,indicating favorable safety profiles across age groups.Conclusion The Liwen procedure significantly improves left ventricular outflow tract obstruction and reduces IVST in OHCM patients,Moreover,it demonstrates reliable safety in patients across different age groups.
Keywords：Hypertrophic obstructive cardiomyopathyLiwen procedureAgeEfficacySafety
Publication Date：2026-01-25
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：6( 42-47 )