Progress in the study of hypoxic pulmonary hypertension
LIN Yue
HAN Jun-jun
LIU Gui-qin
LI Xiang-yang
REN Ming
Abstract：The homeostatic regulation of the cardiovascular system often faces great challenges under the special physiological environmental stress of hypoxia in plateaus,and hypoxia is a key causative factor for cardiovascular diseases.Hypoxic pulmonary hypertension(HPH),as a common disease under chronic hypoxic exposure,is characterized by pulmonary vascular dynamic disorder and structural remodeling of the pulmonary vasculature and presents abnormal pulmonary vasoconstrictor response,vascular wall thickening and smooth muscle cell proliferation,which ultimately results in the persistent vicious circle of elevated pulmonary artery pressure.This paper provides new ideas for the clinical treatment of HPH by summarizing the modeling modality,pathological mechanisms and treatment methods of HPH.
Keywords：Hypoxic pulmonary hypertensionModeling modalitiesPathological MechanismsTreatment Methods
Publication Date：2025-12-20
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：6( 1082-1087 )