Research progress of the ankyrin repeat and SOCS box containing 10/heat shock protein 70 axis for the treatment of chronic heart failure
ZHOU Jing
WANG Xin-xin
LIU Yong-ming
Abstract：The pathophysiological mechanisms of chronic heart failure are complex,involving multiple processes such as cardiomyocyte apoptosis and oxidative stress.The imbalance of the Ankyrin Repeat and SOCS Box Containing 10(Asb10)/Heat Shock Protein 70(HSP70)axis plays a key role in its development.Asb10,acting as an E3 ubiquitin ligase,mediates HSP70 degradation,thereby weakening its anti-apoptotic,antioxidant,and mitochondrial protective functions.Currently,strategies targeting this axis—including small molecule inhibitors,gene therapies,and biologics—have shown promising potential.When combined with conventional drugs like angiotensin-converting enzyme inhibitor(ACEI)and beta-blockers,these therapies can produce synergistic effects.However,challenges remain,including insufficient specificity and low delivery efficiency.Future research should focus on precise regulation and timely spatiotemporal dynamic interventions to advance chronic heart failure treatment from symptom-based approaches to mechanism-targeted therapies.
Keywords：Chronic heart failureAnkyrin repeat and SOCS box containing 10/heat shock protein 70 axisTargeted therapySmall molecule inhibitorsGene therapyCombination strategy
Publication Date：2025-12-20
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：6( 1076-1081 )