Research progress of LMNA gene mutations in dilated cardiomyopathy
ZHU Ling-min
YU Ming-yang
WANG Guang-qiang
Abstract：LMNA gene mutations are a significant genetic cause of dilated cardiomyopathy(DCM),disrupting the function of lamin A/C proteins and leading to cardiomyocyte dysfunction and structural remodeling.Clinically,LMNA-associated DCM is characterized by early-onset,rapidly progressive left ventricular dilation and systolic dysfunction with a high incidence of malignant arrhythmias associated with sudden cardiac death.Treatment requires a combination of anti-heart failure medications,device-based interventions,and targeted therapies.Moreover,research on potential pathways such as PDGF and the E2F/DDR/TP53 axis points to future directions.Genetic counseling and testing are crucial for familial disease management.This review systematically summarizes the mechanisms,clinical management,and therapeutic advancements of LMNA-related DCM.
Keywords：LMNA gene mutationsDilated cardiomyopathy
Publication Date：2025-10-20
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：6( 893-898 )