The association between metabolically healthy obesity and uric acid levels and 10-year cardiovascular disease risk
ZHANG Shu-yan
SUN Ya-zhao
SUN Pei
BAI Chun-lan
LIU Ya-yun
MA Ya
LI Yong-le
XU Xin-xin
CUI Shi-wei
Abstract：Objective To explore the relationship between renal function indicators and metabolically healthy obesity(MHO),while also assessing the association between MHO and 10-year cardiovascular disease risk.Methods Data for this study were derived from the China Health and Retirement Longitudinal Study(CHARLS)database.Participants were classified into four obesity-metabolic phenotypes based on body mass index(BMI)and metabolic status:metabolically healthy non-obese(MHNO,n=2512),metabolically unhealthy non-obese(MUNO,n=2354),MHO(n=566),and metabolically unhealthy obese(MUO,n=1742).Univariate and multivariate Logistic regression analyses were used to investigate the association between renal function indicators and MHO,as well as the relationship between MHO and 10-year cardiovascular disease risk.Results Among the 7174 participants,the prevalence of MHO was 7.89%,while the prevalence of MHO among obese adults was 24.52%.Significant differences were observed among the four phenotypes in serum uric acid(SUA)and serum creatinine(Scr)levels.Multivariate Logistic regression analysis showed that after adjusting for confounding factors,SUA was positively associated with MHO(OR=1.20,95%CI 1.11-1.29,P<0.001).Furthermore,MHO was positively associated with a moderate to high 10-year cardiovascular disease risk as assessed by the Framingham score(OR=2.54,95%CI 1.46-4.35,P<0.001).Conclusion SUA was independently associated with MHO.MHO was independently associated with a moderate to high 10-year cardiovascular disease risk as assessed by the Framingham score.
Keywords：ObesityMetabolic status10-year cardiovascular eventsFraminghamSerum uric acid
Publication Date：2025-08-20
Online Publishing Date：2025-09-05(First online date of this platform, not the publication date of the document)
Pages：6( 680-685 )