Relationship between serum long-chain noncoding RNA plasmacytoma diverse heterozygotes 1,long-chain noncoding RNA H19 and ventricular arrhythmia secondary to myocardial infarction

YUAN Fang; WANG Cong-cong; SONG Hai-ping

doi:10.3969/j.issn.1672-5301.2025.07.012

Abstract：Objective To explore the relationship between serum long non-coding RNA(lncRNA)multiectopic gene 1(PVT1),lncRNA H19 and ventricular arrhythmia secondary to acute myocardial infarction(AMI).Method A total of 216 patients with AMI treated in Handan Central Hospital from November 2021 to November 2023 were recorded as AMI group.According to Lown grading criteria,the patients were divided into no ventricular arrhythmia group(135 cases)and ventricular arrhythmia group(81 cases).A total of 216 healthy subjects who underwent physical examination with our hospital were selected as the control group.The expression of lncRNA PVT1 and lncRNA H19 in serum was detected by qRT-PCR.The influencing factors of secondary ventricular arrhythmias in AMI were analyzed by Logistic regression.ROC curve analysis of serum lncRNA PVT1 and lncRNA H19 expression value in the prediction of AMI secondary ventricular arrhythmia.Result Compared with control group,serum lncRNA PVT1 and lncRNA H19 levels in AMI group were significantly increased(P<0.05).Compared with no ventricular arrhythmia group,TG and LDL-C levels in ventricular arrhythmia group were significantly increased(P<0.05).Compared with no ventricular arrhythmia group,serum lncRNA PVT1 and lncRNA H19 in ventricular arrhythmia group were significantly increased(P<0.05).Multivariate Logistic regression analysis showed that lncRNA PVT1(OR=2.571,P<0.001)and lncRNA H19(OR=2.993,P<0.001)with high expression were risk factors for secondary ventricular arrhythmias in AMI patients(P<0.05).The AUC predicted by serum lncRNA PVT1 and lncRNA H19 for secondary ventricular arrhythmia in AMI patients was 0.843(95%CI 0.788-0.889)and 0.851(95%CI 0.796-0.896),respectively,and the AUC predicted by the combination of the two was 0.913(95%CI 0.867-0.947).It was significantly higher than that predicted by single index(Zcombination-lncRNA H19=2.444,Zcombination-lncRNA PVT1=2.012,P=0.016,P=0.044).Conclusion lncRNA PVT1 and lncRNA H19 expression levels were elevated in patients with AMI secondary ventricular arrhythmias,which had certain predictive value for AMI secondary ventricular arrhythmias,and their combined prediction efficiency was higher.