Analysis of characteristics and risk factors of atrial fibrillation in young and middle-aged patients
LI Ya-fang
QI Qi
LI Wan-song
HAN Quan-le
WANG Li-yan
ZHANG Ai-li
CAO Hong-xia
TIAN Li-ying
WU Shou-ling
LI Kang-bo
Abstract：Objective To explore the characteristics of atrial fibrillation(AF)and its associated risk factors in the young and middle-aged adults.Methods Using a cross-sectional study design,the young and middle-aged individuals(age＜60 years)who underwent health examinations at Kailuan group from June 2006 to December 2018 were selected.A 1∶4 matching ratio was applied to match AF patients with non-AF patients during the same period,resulting in 710 AF patients matched with 2840 non-AF patients,with a total of 3550 participants included in this study.Statistical analysis was conducted to investigate the characteristics and risk factors of AF in this population.Results Compared with the non-AF group,the AF group showed statistically significant differences in levels of fasting blood glucose(FBG),diastolic blood pressure(DBP),body mass index(BMI),total cholesterol(TC)and high-sensitivity C-reactive protein(Hs-CRP),as well as in the proportions of hypertension history,diabetes history and cardiovascular disease(CVD)(P＜0.05).The AF group had higher levels of FBG,DBP,BMI and Hs-CRP,and also a higher proportion of hypertension history,diabetes history and CVD[(6.14±2.26)mmol/L vs.(5.88±1.98)mmol/L,(85.52±12.56)mmHg vs.(84.43±11.40)mmHg,(25.78±3.66)kg/m2 vs.(25.18±3.29)kg/m2,1.24(0.50,3.40)mg/L vs.1.10(0.40,2.91)mg/L,58.03％vs.45.49％,18.45％vs.11.83％,10.85％vs.7.18％],but a lower TC level compared with the non-AF group[(4.71±1.39)mmol/L vs.(4.98±1.29)mmol/L].Multivariate conditional Logistic regression analysis revealed that BMI(OR=1.05,95％CI 1.02-1.09),history of hypertension(OR=1.44,95％CI 1.15-1.80),Hs-CRP(OR=1.02,95％CI 1.01-1.04)and diabetes(OR=1.58,95％CI 1.05-2.36)were the risk factors for AF(P＜0.05).TC(OR=0.82,95％CI 0.75-0.89)was a protective factor against AF(P＜0.05).Conclusions High BMI,history of hypertension,diabetes history and high-sensitivity C-reactive protein are the independent risk factors for AF,while TC was found to be a protective factor against AF in this demographic.
Keywords：Young and middle-aged populationAtrial fibrillationRisk factorCholesterol paradox
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 442-446 )