Study on the relationship between lifestyle and serum levels of oxidative stress markers in the young and middle-aged individuals
SONG Jia-yi
YUAN Kun
LI Chong-jian
CHU Jun-min
HUANG Yi-lin
DONG Li-guang
MU Lin
TIAN Xiao-yuan
WANG Hong-yu
LIU Jin-bo
AN Xin-hua
YANG Ying
TIAN Ye
WANG Zeng-wu
ZHANG Lin-feng
Abstract：Objective To explore the relationship between lifestyle and major oxidative stress biomarkers in young and middle-aged individuals.Methods In January 2022 and from August to September 2023,a random sample of residents aged 18 years and above was selected from the Pingguoyuan and Wulituo Street in Shijingshan District,Beijing for questionnaire survey and physical examination,and fasting venous blood was collected for laboratory testing.Multiple linear regression analysis was used to explore associations between the lifestyle variables and serum oxidative stress biomarkers.Results A total of 651 young and middle-aged individuals aged 18-54 years were included in this study,including 338 males(51.9％)and 313 females(48.1％).Correlation analysis showed significant associations between several lifestyle factors and the levels of five oxidative stress biomarkers:superoxide dismutase(SOD),glutathione peroxidase 3(GPX3),malondialdehyde(MDA),oxidized low-density lipoprotein(oxLDL)and paraoxonase 1(PON1).After adjusting for confounders in multiple linear regression models,sleep duration was found to be positively correlated with SOD activity,while smoking and egg consumption were positively correlated with GPX3 levels,and moderate or greater physical activity was positively correlated with oxLDL levels(β=0.029,52.514,0.363,0.004,P＜0.05).Conversely,sleep duration was negatively correlated with MDA levels,egg consumption and sleep duration were negatively correlated with oxLDL levels,and smoking and sleep duration were negatively correlated with PON1 levels(β=-0.031,-0.005,-0.007,-5.043,-0.040,P＜0.05).These associations were also observed in the sex-stratified analysis.Conclusion Lifestyle is closely related to the levels of common oxidative stress biomarkers in the bodies of the young and middle-aged people.Young and middle-aged individuals can regulate their oxidative stress status by improving their lifestyle.
Keywords：LifestyleOxidative stressSerum biomarkersYoung and middle-aged people
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 373-379 )