Postoperative neurological complications of domestically produced fully magnetically levitated left ventricular assist device:A single-center clinical study
ZHANG Hao-tian
ZHOU Xing-tong
CHEN Hai-bo
CHEN Kai
DU Juan
ZOU Liang
CHEN Yi
QING Ping
JIN Yan
ZHANG Yan-ming
YIN Ze-lin
ZHANG Ze
WANG Xian-qiang
Abstract：Objective To evaluate the incidence and clinical characteristics of neurological complications following implantation of the domestically developed fully magnetically levitated centrifugal pump(CH-VAD).Methods 93 patients with end-stage heart failure who underwent CH-VAD implantation at Fuwai Hospital,Chinese Academy of Medical Sciences,from June 2017 to January 1,2025 were included in this retrospective study.Neurological complications(ischemic/hemorrhagic stroke or transient ischemic attack)were defined according to INTERMACS criteria.The survival rates were analyzed using Kaplan-Meier curves,and group comparisons were performed with log-rank tests.Results The median follow-up was 406(194,1262)days,with 8 patients(8.60％)experiencing the neurological complications(annualized incidence rate:0.04 events per patient-year),including 1 case of disabling stroke.The complication group exhibited significantly higher preoperative risks:ventricular tachycardia/fibrillation(62.50％vs.23.53％,P=0.030),stroke history(37.50％vs.7.06％,P=0.028),CRT-D implantation rate(37.50％vs.2.35％,P=0.004),severe aortic regurgitation(37.50％vs.5.88％,P=0.028)and elevated N-terminal pro-brain natriuretic peptide(NT-proBNP)levels(7985.00 vs.2869.50 pg/ml,P=0.032).Survival analysis demonstrated overall survival rates of 94.2％at 2 years and 90.5％at 3 years,with neurological complication-free survival rates of 95.0％at 2 years and 91.2％at 3 years.Conclusion CH-VAD demonstrated a low incidence of neurological complications,likely attributable to its fully magnetically levitated design,low rotational speed impeller and optimized flow paths,which reduce blood trauma.Preoperative ventricular arrhythmias,stroke history,elevated NT-proBNP levels and the valvular pathologies warrant vigilant risk stratification and personalized management.
Keywords：Left ventricular assist deviceNeurological complicationsFull magnetic levitationHemocompatibilityEnd-stage heart failure
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 321-325 )