Association of macrophage lectin-1 expression level with the risk of rehospitalization in patients with chronic stable angina pectoris and its clinical value

SHI Lin; Kadeyanmu·ABULIMITI; ZHANG Yu-lin; XU Ying-ming; YAN Fei

doi:10.3969/j.issn.1672-5301.2025.03.005

Abstract：Objective To evaluate the relationship between macrophage lectin-1(MDL-1)mRNA expression levels and the risk of rehospitalization in patients with stable angina pectoris(SAP),and to explore the potential of MDL-1 as a biomarker for early diagnosis and risk assessment in SAP patients.Methods A total of 109 newly diagnosed SAP patients were recruited from the First Affiliated Hospital of Xinjiang Medical University between May 2021 and May 2022,alongside 100 age-and sex-matched healthy controls.MDL-1 mRNA and protein expression levels in peripheral blood mononuclear cells(PBMC)were measured using qRT-PCR and Western blot.Based on the median MDL-1 mRNA expression levels,patients were divided into high-expression and low-expression groups.Patients were followed for two years to monitor rehospitalization events.Kaplan-Meier survival curves,Cox regression,and ROC curve analyses were used to assess the predictive value of MDL-1 mRNA expression levels for rehospitalization risk,while binary Logistic regression was employed to determine the independent association between MDL-1 expression and rehospitalization risk.Results High MDL-1 mRNA expression was significantly associated with an increased risk of rehospitalization in SAP patients.The rehospitalization rate was notably higher in the high-expression group compared to the low-expression group.Kaplan-Meier survival analysis revealed a significant difference in rehospitalization-free survival between the two groups(P<0.001).Cox regression analysis identified high MDL-1 expression as an independent predictor of rehospitalization(HR=3.002,95%CI 1.781-5.059).Binary Logistic regression further confirmed that patients with high MDL-1 expression had a significantly increased risk of rehospitalization(OR=4.349,95%CI 2.056-9.2013,P<0.011).In addition,hypertension was found to be another significant predictor of rehospitalization in SAP patients(OR=2.9647,95%CI 1.069-8.217,P=0.037).Conclusion Elevated MDL-1 mRNA expression significantly increases the risk of rehospitalization in SAP patients and demonstrates potential as a biomarker for early screening and risk assessment.MDL-1 could serve as an important biomarker for prognostic evaluation in SAP,guiding individualized treatment for high-risk patients.