Correlation between lipid metabolism indicators with inflammatory cytokine expression and left ventricular remodeling in chronic heart failure

ZHANG Bin; YIN Peng-fan; SHI Jin-zheng; HONG Yang; MENG Chou-shuan; MA Fang-fang; LI Yong-le

doi:10.3969/j.issn.1672-5301.2025.02.011

Abstract：Objective To explore the relationship between lipid metabolism index,Vaspin,food intake inhibitor 1,adiponectin,C-reactive protein(CRP),interleukin-6(IL-6)and left ventricular remodeling in patients with chronic heart failure.Methods A total of 246 patients with chronic heart failure admitted to the First Affiliated Hospital of Hebei North University from December 2023 to June 2024 were selected.All patients were divided into control group(121 cases)and remodeling group(125 cases)according to whether they had left ventricular remodeling.The left ventricular remodeling related parameters,lipid metabolism indexes,Vaspin,food intake inhibitor-1,adiponectin,CRP,and IL-6 levels were compared between the two groups.Multivariate Logistic regression was used to identify the independent risk factors of left ventricular remodeling.Pearson correlation model was used to analyze the correlation between left ventricular remodeling related parameters and lipid metabolism indicators,Vaspin,food intake inhibitory factor 1,adiponectin,CRP and IL-6 levels.Results Left ventricular end-diastolic dimension(LVEDD),left ventricular end-systolic diameter(LVESd),left ventricular posterior wall thickness(LVPWT),interventricular septal thickness(IVSTd)and left ventricular mass index(LVMI)were significantly higher in the remodeling group than in the control group[(76.84±10.54)mm vs.(67.08±9.47)mm、(78.41±11.38)mm vs.(65.29±10.44)mm、(17.43±4.02)mm vs.(12.19±3.45)mm、(17.64±4.11)mm vs.(12.28±3.51)mm、(149.83±23.19)g/m2 vs.(139.74±21.46)g/m2)],and left ventricular ejection fraction(LVEF)was significantly lower than that in the control group[(35.44±7.69)％vs.(40.18±7.81)％,P＜0.05].Total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)in remodeling group were higher than those in control group[(5.56±1.11)mmol/L vs.(4.71±1.03)mmol/L、(1.75±0.05)mmol/L vs.(1.64±0.04)mmol/L、(1.71±0.16)mmol/L vs.(1.48±0.14)mmol/L、(2.86±0.59)mmol/L vs.(2.55±0.54)mmol/L,P＜0.05].The levels of Vaspin,feeding inhibitory factor 1 and adiponectin in the remodeling group were lower than those in the control group[(0.49±0.05)mg/ml vs.(0.73±0.07)mg/ml、(117.04±21.49)pg/ml vs.(131.57±24.61)pg/ml、(8.36±1.07)mg/L vs.(9.03±1.24)mg/L,P＜0.05].The levels of CRP and IL-6 in the remodeling group were higher than those in the control group(P＜0.05).Logistic multivariate regression analysis showed that the levels of TC,TG,LDL-C,HDL-C,Vaspin,food intake inhibitor-1,adiponectin,CRP and IL-6 were independent risk factors for left ventricular remodeling in patients with chronic heart failure(P＜0.05).Pearson correlation analysis showed that the levels of LVEDD,LVESd,LVPWTs,IVSTd and LVMI were positively correlated with the levels of TC,TG,LDL-C,HDL-C,CRP and IL-6,and negatively correlated with the levels of Vaspin,feeding inhibitory factor 1 and adiponectin.The level of LVEF was negatively correlated with the levels of TC,TG,LDL-C,HDL-C,CRP and IL-6,and positively correlated with the levels of Vaspin,feeding inhibitory factor 1 and adiponectin(P＜0.05).Conclusions Patients with chronic heart failure and left ventricular remodeling show increased levels of lipid metabolism indexes,CRP and IL-6,and decreased levels of Vaspin,feeding inhibitory factor 1 and adiponectin,which are independent risk factors for left ventricular remodeling.The levels of lipid metabolism indexes,Vaspin,feeding inhibitory factor 1,adiponectin,CRP and IL-6 are correlated with left ventricular remodeling in patients with chronic heart failure.