Association of the variants in FERM domain-containing protein 5 and RNA binding motif protein 5 and sorting nexin 13 and very low-density lipoprotein receptor with the risk of hyperlipidemia
GAO Hui
LI Jia-hai
MA Qiao-li
ZHANG Qing-hui
Abstract：Objective To explore the relationship between the single nucleotide polymorphisms(SNP)of FERM domain-containing protein 5(FRMD5),RNA binding motif protein 5(RBM5),sorting nexin 13(SNX13),and very low-density lipoprotein receptor(VLDLR)and the risk of hyperlipidemia in Chinese people.Methods In 2021,2262 participants aged 27-92 years were recruited from Shangqiu City,Henan Province.Genotyping of 4 SNP was performed in 1,191 patients with normal lipidemia,631 with hypercholesterolemia(HCH),and 561 with hypertriglyceridemia(HTG).Results The genotype frequencies of FRMD5 rs2929282,RBM5 rs2013208 and VLDLR rs3780181 SNP were significantly different between the hyperlipidemia and normal lipidemia groups.RBM5 rs2013208 SNP increased the risk of HCH(OR=1.46),VLDLR rs3780181 SNP reduced the risk(OR=0.70),while FRMD5 rs2929282 and RBM5 rs2013208 SNP increased the risk of HTG(OR=1.47,OR=1.37).Conclusion FRMD5 rs2929282,RBM5 rs2013208 and VLDLR rs3780181 SNP are associated with the risk of HCH or HTG in Chinese people.
Keywords：Single-nucleotide polymorphismLipidHypercholesterolemiaHypertriglyceridemia
Publication Date：2025-02-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 146-152 )