Analysis of early clinical results of cardiac contractility modulation implantation in the treatment of heart failure
SU Rong
LIN Ling
ZHANG Ming-guo
YANG Ai-ling
LI Yun-fei
CHEN Yun-yu
Abstract：Objective To investigate the early clinical results of myocardial systolic regulator(CCM)in patients with heart failure.Methods The clinical data of patients with chronic heart failure who underwent CCM implantation in the First Affiliated Hospital of Kunming Medical University from February 2022 to December 2023 were retrospectively analyzed.The patients were followed up 1 month and 6 months after CCM implantation.New York Heart Association(NYHA)cardiac function classification,left atrial diameter(LAD),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)were compared before CCM implantation,1 month and 6 months after CCM implantation.Intraoperative and postoperative complications and adverse events were recorded.Results The 22 patients with CCM implantation and complete data were included.Among them,15 were males,aged(52±10)years,20 were patients with dilated cardiomyopathy,and 2 were patients with chronic heart failure caused by other causes.The results showed that LVEDD decreased gradually at 1 and 6 months after CCM implantation[(63.0±9.8)mm and(59.2±10.6)mm vs.(65.6±8.7)mm,P<0.05].LVEDV decreased 6 months after CCM implantation compared with that before implantation[(201.2±85.7)ml vs.(247.7±75.2)ml,P<0.05].LVESV decreased at 1 and 6 months after implantation compared with that before operation[(130.3±61.3)ml and(117.5±69.2)ml vs.(166.9±64.6)ml,P<0.05].The postoperative LAD was smaller than that before implantation[(39.0±7.3)mm and(38.3±8.1)mm vs.(43.8±7.6)mm,P<0.05].LVEF was significantly higher 1 and 6 months after CCM implantation than that before implantation[(42.0±5.8)%and(47.3±9.2)%vs.(31.6±7.2)%,P<0.05]and the proportion of NYHA Ⅲ-Ⅳ patients decreased compared with before CCM implantation(P<0.05).No complications occurred during the operation.After discharge,2 patients were found to have abnormal parameters due to program control and underwent electrode adjustment surgery for implantable cardioverter defibrillator(ICD).No patients died during the follow-up period,3 patients were readmitted due to acute aggravation of chronic heart failure,and 4 patients(18.2%)were readmitted due to other causes.Conclusion CCM implantated in patients with chronic heart failure promotes cardiac retroremodeling and improved cardiac function in the early stage.
Keywords：Heart failureMyocardial systolic regulatorLeft ventricular ejection fraction
Publication Date：2025-01-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 35-39 )