The role of plaque healing in the development of atherosclerosis
WANG Chen-ye
YE Fu-rong
LIAO Wang
Abstract：Atherosclerotic plaque rupture or erosion with thrombosis is the leading cause of acute coronary syndrome(ACS),but pathological studies have shown that many unstable atherosclerotic plaques do not lead to clinical symptoms,and this model may oversimplify plaque progression and the development of ACS.With the application of intracavitary imaging techniques such as optical coherence tomography(OCT)and intravascular ultrasound(IVUS)in ACS,different plaque characteristics have been more deeply studied.The mechanism of imbalance between instability and healing of atherosclerotic plaques and the role of plaque healing in the development of ACS have attracted increasing attention.The article reviews the role of plaque healing in the progression of atherosclerotic plaques and the development of ACS,and the mechanisms of inflammation,thrombosis,granulation tissue and endothelial cell formation related to plaque healing as well as clinical and potential intervention directions.
Keywords：AtherosclerosisPlaque healingInflammation
Publication Date：2024-11-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 961-966 )