Clinical analysis of risk factors of pericardial effusion after transcatheter closure of left atrial appendage
ZHOU Ming-yao
ZHANG Sha
ZHANG Jing-yu
LYU Tong-wei
CHEN Ke-yu
BAI Yuan
GUO Zhi-fu
Abstract：Objective To investigate the incidence,treatment methods and risk factors of pericardial effusion(PEF)after left atrial appendage closure(LAAC).Methods 502 patients with atrial fibrillation who underwent LAAC at First Affiliated Hospital of Naval Medical University from June 2016 to December 2022 were included.The patients were divided into the PEF group and the non-PEF group based on whether they developed pericardial effusion after LAAC.The Cox proportional hazards regression model was used to explore the risk factors for pericardial effusion.Results A total of 17 cases of PEF occurred after LAAC,with 13 cases requiring percutaneous pericardiocentesis or surgical intervention.All the patients fully recovered during the 25.6-month follow-up period.Compared with the non-PEF group,the patients in the pericardial effusion group had smaller occluder sizes[(23.8±4.4)mm vs.(27.3±4.3)mm,P=0.009]and longer hospital stays[(6.8±7.9)d vs.(19.3±14.9)d,P＜0.0001].Multivariate analysis indicated that paroxysmal atrial fibrillation(OR=4.578,95％CI 1.102-19.024;P=0.036),a history of major bleeding(OR=4.969,95％CI 1.150-21.470;P=0.032)and lack of operating experience(OR=6.036,95％CI 1.915-19.028;P=0.002)were the independent risk factors for PEF.Conclusion PEF is a common complication after LAAC.Paroxysmal atrial fibrillation,a history of major bleeding and inexperienced operators increase the risk of pericardial effusion.The size of the occluder is also associated with the occurrence of PEF.
Keywords：Pericardial effusionLeft atrial appendage occlusionRisk factors
Publication Date：2024-10-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 889-894 )