Application value of combined detection of serum N-terminal pro-brain natriuretic peptide,insulin-like growth factor binding protein 7 and heat shock protein 47 in the diagnosis of patients with chronic heart failure
ZHANG Hua
SONG Min
TIAN Mei-rong
Abstract：Objective To explore the application value of combined detection of serum N-terminal pro-brain natriuretic peptide(NT-proBNP),insulin-like growth factor binding protein 7(IGFBP7)and heat shock protein 47(HSP47)in the diagnosis of patients with chronic heart failure(CHF).Methods 106 CHF patients who admitted to our hospital from December 2021 to December 2023 were used as the CHF group,and 106 healthy individuals who underwent physical examinations same time were as the control group.The expression levels of NT-proBNP,IGFBP7 and HSP47 in the serum were measured using enzyme-linked immunosorbent assay(ELISA).The factors affecting the occurrence of CHF were analyzed using multiple logistic regression analysis.Diagnostic value of serum NT-proBNP,IGF-BP7 and HSP47 in patients with CHF was analyzed by drawing the receiver's operating characteristics(ROC)curve.Results Compared with the control group,the expression levels of NT-proBNP,IGFBP7 and HSP47 in the serum of the CHF group were obviously increased(t=0.960,8.047,11.196,P＜0.05).Multivariate logistic regression showed that serum NT-proBNP,IGFBP7 and HSP47 were the risk factors affecting the occurrence of CHF(P＜0.05),while left ventricular ejection fraction(LVEF)was a protective factor affecting the occurrence of CHF(P＜0.05).The combing test of the serum NT-proBNP,IGFBP7 and HSP47 had the highest AUC in the diagnosis of CHF,which was higher than that detected alone(Ztriplecombination-NT-proBNP=3.847,P=0.001,Ztriple combination-IGFBP7=4.672,P＜0.001,Ztriple combination-HSP47=2.101,P=0.036).Conclusion The expression levels of NT-proBNP,IGFBP7 and HSP47 in the serum of CHF patients are elevated,and the combing text of the three has the best diagnostic efficacy for CHF.
Keywords：N-terminal pro-brain natriuretic peptideInsulin-like growth factor binding protein 7Heat shock protein 47Chronic heart failureDiagnosis
Publication Date：2024-10-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 884-888 )