Macrophage migration inhibitory factor and left ventricular hypertrophy in patients with essential hypertension
SHAN Xue-feng
Abudushalamu KASIMUJIANG
YANG Long
GAO Xiao-ming
Abstract：Objective To investigate the relationship between macrophage migration inhibitory factor(MIF)and left ventricular hypertrophy(LVH)in patients with essential hypertension,and to investigate the role of MIF in the development of LVH in these patients.Methods A total of 802 patients with essential hypertension who were diagnosed and treated at the Department of Cardiology,First Affiliated Hospital of Xinjiang Medical University from January 2019 to September 2020 were included.The patients'gender,ethnicity,age,smoking history,alcohol consumption history,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI)and echocardiographic parameters were recorded.The serum MIF level was measured using the ELISA method.Left ventricular mass(LVM)and left ventricular mass index(LVMI)were calculated using the Devereux formula.The patients were divided into the LVH group(n=136)and the non-LVH group(n=666)based on their LVMI levels(male＞125 g/m2,female＞120 g/m2).Scatter plots were created,and Spearman correlation analysis was performed to assess the association between MIF and LVM and LVMI.Multivariate logistic regression was used to analyze the factors influencing LVH in hypertensive patients.The ROC curve was plotted to evaluate the predictive ability of MIF for LVH in hypertensive patients.Results The MIF level in the LVH group was significantly higher than thas in the non-LVH group[124.77(79.05,141.58)ng/ml vs.69.07(51.76,88.08)ng/ml,P＜0.05].Additionally,the LVH group had the higher proportions of male,coronary heart disease history,older age,longer hypertension duration and higher systolic blood pressure compared to the non-LVH group(P＜0.05).Spearman correlation analysis showed that MIF was positively correlated with both LVM(r=0.270)and LVMI(r=0.320).Multivariate logistic regression analysis indicated that MIF(OR=1.029,95％CI 1.023-1.036,P＜0.001),systolic blood pressure(OR=1.013,95％CI 1.003-1.024,P=0.013),male gender(OR=1.997,95％CI 1.169-3.472,P=0.012)and alcohol consumption(OR=0.356,95％CI 0.173-0.704,P=0.004)were the factors influencing the development of LVH in hypertensive patients.The ROC curve analysis showed that the area under the curve(AUC)for MIF in predicting LVH in hypertensive patients was 0.777(95％CI 0.725-0.829,P＜0.001).Conclusion MIF is associated with the left ventricular hypertrophy in patients with essential hypertension,suggesting that MIF may play a role in the process by which hypertension affects cardiac function.
Keywords：Macrophage migration inhibitory factorEssential hypertensionLeft ventricular hypertrophyLeft ventricular massLeft ventricular mass index
Publication Date：2024-10-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 865-871 )