Association of triglyceride-glucose index and echocardiographic indexes with heart failure

MA Ji-yuan; LIU Dan-dan; JIANG Wen-xi

doi:10.3969/j.issn.1672-5301.2024.09.011

Abstract：Objective To assess the changes of triglyceride glucose(TyG)index and echocardiographic indexes in heart failure(HF),analyse the risk factors related to HF,and explore the dose-response relationship between TyG index and HF.Methods A total of 149 HF patients(HF group)and 89 non-HF patients(non-HF group)who were hospitalized in the Department of Cardiovascular Medicine of the Fifth Affiliated Hospital of Xinjiang Medical University from January 2020 to December 2022.The clinical data,laboratory indexes and echocardiographic indexes were analyzed,and the TyG index was calculated.Binary logistic regression analysis was used to derive the risk factors for HF;the predictive value of TyG index and echocardiographic indexes for HF were evaluated using the receicer operating characteristic(ROC)curve,and the restricted cubic spline(RCS)model was constructed to clarify the dose-response relationship between the TyG index and HF.Results Logistic regression showed that left ventricular end-diastolic diameter(LVEDD),right ventricular diameter(RVD),right atrial diameter(RAD)and left atrial diameter(LAD)were the risk factors for HF,with ORs of 1.147(95％CI 1.093-1.204),1.491(95％CI 1.309-1.698),1.292(95％CI 1.193-1.400),1.431(95％CI 1.303-1.571),but the fractional shortening(FS)and TyG index were the protective factors for HF with OR 0.756(95％CI 0.699-0.817)and 0.175(95％CI 0.087-0.351).The results of the RCS model showed a dose-response relationship between the TyG index and HF(Pnon-linear=0.521,Poverall=0.008).Conclusion Low level of TyG index(TyG≤9)would be a protective factor for HF and have some value in the prediction of HF,with a linear-dose-response relationship between them.