Correlation of serum fatty acid binding protein 4 and phosphatidylinositol-3-kinase with heart failure

LI Yun; XIA Ming-zhu; YANG Hai-chen; ZHAO Jin-fang; ZHU Lei; GUO Meng

doi:10.3969/j.issn.1672-5301.2024.09.010

Abstract：Objective To investigate the relationship between the levels of serum fatty acid binding protein 4(FABP4)and phosphatidylinositol 3-kinase(PI3K)and the occurrence and development of heart failure(HF).Methods 89 patients with heart failure hospitalized in the Department of Cardiology of the First Affiliated Hospital of Anhui University of Science and Technology from October 2023 to April 2024 were selected,of which 41 were in the group of cardiac function class Ⅲ and 48 were in the group of cardiac function class Ⅳ,as well as 89 patients who were admitted to the hospital for the examination and exclusion of heart failure in the same period as the control group.The serum levels of FABP4 and PI3K in each group were measured by ELISA to observe the differences and clinical significance of the two between different subgroups;and Pearson correlation analysis was applied to further analyze the correlation between both FABP4 and PI3K and N-terminal-B-type natriuretic peptide precursor(NT-proBNP).Results The age,left atrial anteroposterior diameter(LAD),left ventricular end-diastolic internal diameter(LVDD),left ventricular end-systolic internal diameter(LVSD),N-terminal-B-type natriuretic peptide precursor(NT-proBNP),creatinine(Cr),C-reactive protein(CRP),and fasting glucose(FPG)levels of the patients in the cardiac function class Ⅲ and class Ⅳ groups were higher than that in the control group,whereas the levels of triglycerides(TG),left ventricular ejection fraction(LVEF)and left shortening fraction(FS)levels were lower than those in the control group(P＜0.05);serum FABP4 expression levels were higher in the cardiac function class Ⅲ and cardiac function class Ⅳ groups than those in the control group[(64.32±21.58)ng/ml vs.(75.20±26.37)ng/ml vs.(54.16±15.45)ng/ml,P＜0.05],but serum PI3K expression level was lower than that of the control group[(889.07±1 55.23)U/L vs.(763.53±184.60)U/L vs.(980.37±201.86)U/L,P＜0.05].Compared with the cardiac function class Ⅲ group,serum FABP4 expression level was increased in the cardiac function class Ⅳ group[(75.20±26.37)ng/ml vs.(64.32±21.58)ng/ml,P＜0.05],serum PI3K expression level was decreased[(763.53±184.60)U/L vs.(889.07±155.23)U/L,P＜0.05].The Pearson correlation analysis showed that FABP4 level was positively correlated with the level of NT-proBNP(r=0.711,P＜0.05),but PI3K was negatively correlated with NT-proBNP(r=-0.803,P＜0.05),and FABP4 was negatively correlated with the level of PI3K(r=-0.434,P＜0.05)in all the experimental groups.Conclusion The expression level of FABP4 in the serum of HF patients is significantly higher and gradually increase with the raise of the cardiac function grading,but the expression level of PI3K appears just opposite to FABP4,and both they have a certain correlation with NT-proBNP.