Relationship between glycosylated hemoglobin/apolipoprotein A1 ratio,C-reactive protein to high-density lipoprotein cholesterol ratio and neutrophil-to-lymphocyte ratio and coronary heart disease

XU Ying; LIU Xiao-chen

doi:10.3969/j.issn.1672-5301.2024.09.009

Abstract：Objective To investigate the relationship between glycosylated hemoglobin/apolipoprotein A1(HbA1c/ApoA1)ratio,C-reactive protein to high-density lipoprotein cholesterol ratio(CHR)and neutrophil-to-lymphocyte ratio(NLR)and coronary heart disease.Methods A total of 200 patients with coronary heart disease(the coronary heart disease group)who were examined and treated in Xuzhou Central Hospital due to chest pain from March 2020 to March 2022,and 100 patients without coronary heart disease(the non-coronary heart disease group)were selected as the research subjects.According to the Syntax score,the patients with coronary heart disease were divided into the mild group,moderate group and severe group.Peripheral blood HbA1c/ApoA1 ratio,CHR and NLR were compared among the three groups.The correlation between HbA1c/ApoA1 ratio,CHR and NLR and Syntax score in the patients with coronary heart disease was analyzed.ROC curves were plotted to analyze the value of HbA1c/ApoA1 ratio,CHR and NLR in predicting severe coronary artery lesions.HbA1c/ApoA1 ratio,CHR and NLR in the major adverse cardiovascular events(MACE)group and the non-MACE group were comparatively analyzed.Multivariate logistic regression analysis was conducted to screen the independent influencing factors of the degree of coronary artery lesions.Results HbA1c/ApoA1 ratio,CHR and NLR in the coronary heart disease group were higher than those in the non-coronary heart disease group(P＜0.05).As the degree of coronary artery lesions increased,the HbA1c/ApoA1 ratio,CHR and NLR in patients with coronary heart disease increased(P＜0.05).HbA1c/ApoA1 ratio,CHR and NLR in patients with coronary heart disease were positively correlated with Syntax score(r=0.289,0.279,0.277,P＜0.05).The area under the ROC curve of combination of HbA1c/ApoA1 ratio,CHR and NLR for predicting severe coronary artery lesions in patients with coronary heart disease was 0.863,which was larger than that of prediction using any a single indicator.The HbA1c/ApoA1 ratio,CHR and NLR in the MACE group were higher than those in the non-MACE group(P＜0.05).Multivariate logistic regression analysis showed that HbA1c/ApoA1 ratio,CHR and NLR were the independent influencing factors of the degree of coronary artery lesions(P＜0.05).Conclusion HbA1c/ApoA1 ratio,CHR and NLR in patients with coronary heart disease are closely related to the degree of coronary artery lesions.Early detection can help to predict the prognosis(MACE).