Association between systemic immune inflammation index and ventricular arrhythmia after reperfusion in patients with acute myocardial infarction
Ailifeire AIHAITI
MA Yi-ping
LIU Ke
Maidinaimu ABULIZI
Kadierya YIBULAYIN
Muyesai NIJIATI
Abstract：Objective To evaluate the association between systemic immune inflammation index(SII)and the risk of ventricular arrhythmia(VA)after reperfusion therapy in patients with acute myocardial infarction(AMI).Methods A total of 815 patients who were diagnosed with AMI and underwent percutaneous coronary intervention(PCI)in the People's Hospital of Xinjiang Uygur Autonomous Region from January 2023 to April 2024 were selected.According to the median SII level,the patients were divided into two groups:the low-SII group(n=349)and the high-SII group(n=350).The outcome was the occurrence of postoperative VA.Logistic regression analysis was used to evaluate the association between SII and postoperative VA in patients with AMI,and the restricted cubic spline(RCS)was used to evaluate the dose-response relationship between the two variables.ROC curve was used to analyze the predictive ability of SII for postoperative VA events,and subgroup analysis was performed to test the robustness of the results.Results Of the 699 enrolled patients last,193(27.6％)had ventricular arrhythmias.After adjusting for the potential confounders,the risk of ventricular arrhythmia in patients with AMI increased by 0.72 times(OR=1.72,95％CI 1.32-2.24,P＜0.001)for each standard deviation increase in SII.Compared with the low SII group,the risk of VA in AMI patients in the high SII group increased by 1.42 times(OR=2.42,95％CI 1.44-4.07,P=0.001).RCS showed that there was a linear dose-response relationship between SII and the risk after reperfusion in AMI patients(P nonlinear=0.056).ROC curve analysis showed that the area under the curve(AUC)of SII for predicting ventricular arrhythmia after PCI in AMI patients was 0.749(95％CI 0.704-0.795),the sensitivity was 70.9％,and the specificity was 71.5％.Subgroup analysis suggested that high SII level was more strongly associated with the risk of ventricular arrhythmia after PCI in male AMI patients aged?60 years compared with patients aged＜60 years and female patients.Conclusion Increasing SII is significantly associated with increasing risk of VA after reperfusion in AMI patients,and the risk of VA increases progressively with the increase of SII level.
Keywords：Systemic immune inflammation indexAcute myocardial infarctionReperfusionVentricular arrhythmiaRelevance
Publication Date：2024-09-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 769-774 )