Relationship between ultrasound hemodynamic parameters and the degree of carotid artery stenosis and transient ischemic attack
WU Yan
QIU Yun
DUAN Mai-ye
WU Cong-jun
Abstract：Objective To explore the correlation between ultrasound hemodynamic parameters and the degree of carotid artery stenosis and transient ischemic attack(TIA).Methods TIA patients(the study group,n=80)admitted to Xi'an Hi-tech Hospital from November 2022 to October 2023 and healthy physical examination subjects(the control group,n=80)in the same period were selected.The study group was subdivided into Group A(mild stenosis,n=30),Group B(moderate stenosis,n=28),and Group C(severe stenosis,n=22)using digital subtraction angiography(DSA)as the gold standard.DSA and ultrasound were performed in both the study group and control group,and the correlation between ultrasound hemodynamic parameters and the degree of carotid artery stenosis was analyzed.The influence of hemodynamic parameters on TIA was analyzed by multivariate logistic regression.The diagnostic value of hemodynamic parameters for TIA was analyzed using receiver operating characteristic(ROC)curves.Results Compared with control group[(89.12±14.89)cm/s,(91.57±10.56)cm/s,(31.99±8.29)cm/s],peak systolic blood velocity(PSV)[(82.01±10.08)cm/s,(76.81±9.01)cm/s,(71.68±8.04)cm/s],end diastolic blood velocity(EDV)[(87.06±9.62)cm/s,(82.01±9.01)cm/s,(77.02±8.12)cm/s]and mean flow velocity(MV)[(27.58±9.13)cm/s,(22.15±9.63)cm/s,(17.46±4.12)cm/s]were lower,and groups B and C were lower than group A,and group C was lower than group B(P＜0.05).The pulse index(PI,1.52±0.40),resistance index(RI,1.11±0.03)in group C were higher than groups A[(1.19±0.34)、(0.71±0.22)],group B[(1.22±0.37、0.81±0.28)]and control group[(1.52±0.40、l.l1±0.03)],and RI in group B was higher than control group[(0.81±0.28)vs.(0.62±0.24),P＜0.05].The degree of carotid stenosis showed a negative correlation with PSV,EDV and MV(r=-0.786,-0.767,-0.541,P＜0.05).The degree of carotid artery stenosis showed a weak positive correlation with PI and RI(r=0.281,0.318,P＜0.05).PSV(OR=3.047,95％CI 1.602-5.794),EDV(OR=2.743,95％CI 1.509-4.987),MV decrease(OR=1.887,95％CI 1.238-2.876),hypertension(OR=1.926,95％CI 1.356-3.772)and diabetes mellitus(OR=2.104,95％CI 1.473-3.030)were all the independent risk factors for TIA(P＜0.05).PSV,EDV and MV alone and combined to evaluate the TIA,AUC was 0.773(0730-0.813),0.729(0.683-0.771),0.719(0.673-0.762),0.942(0.913-0.963),respectively.Conclusion Ultrasound hemodynamic parameters can monitor hemodynamic changes in TIA patients,among which PSV,EDV and MV are closely related to the degree of carotid artery stenosis,and can serve as a reliable basis for diagnosing TIA.
Keywords：Transient ischemic attackCarotid artery stenosisUltrasoundHemodynamics
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 725-729 )