Role of complement C1q in atherosclerosis
LIU Yu-song
Zhu Hong-tao
Abstract：Atherosclerosis(AS)is a chronic vasculitic disease caused by injury and activation of endothelial cells,followed by abnormal lipid metabolism resulting in lipid accumulation,endothelial dysfunction,platelet activation,vascular inflammatory response,calcification and fibrosis,triggering vascular stenosis and activation of inflammatory pathways.The complement system is an important part of innate immunity,and complement C1q plays a dual role in AS.In the classical pathway,C1q activates the complement system to promote the development of AS.However,C1q can also inhibit the development of AS through various mechanisms such as reducing the formation of foam cells,reducing the pro-inflammatory cytokine signal of macrophages and enhancing the survival ability of macrophages.In addition,as a new stimulating risk gene for atherosclerosis,the development of genetic markers based on the molecular characteristics of C1q-related genes may effectively diagnose and predict the occurrence and progression of AS.This article reviews the role of complement C1q in AS and its role AS a gene for predicting AS.
Keywords：Cardiovascular diseasesCoronary atherosclerosisComplement systemThe complementC1q
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 695-699 )