Study on the changes of serum index levels in patients with coronary heart disease and their relationship with disease progression

SHI Wen-jie; ZHANG Hui-na; HASIDAER Midilibieke; LIU Cheng

doi:10.3969/j.issn.1672-5301.2024.07.005

Abstract：Objective To investigate the expression of serum lipoprotein phospholipase A2(Lp-PLA2),CX3C chemokine ligand 1(CX3CL1)and fibroblast growth factor-23(FGF23)and their relationship with disease progression in patients with coronary artery disease.Methods A total of 324 patients with coronary artery disease admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2021 to September 2023 were selected as the case group,and they were divided into the mild(76 cases),moderate(145 cases)and severe(103 cases)groups according to the degree of disease progression;meanwhile,380 healthy people who underwent physical examination in the same hospital were selected as the control group.The basic data and serum Lp-PLA2,CX3CL1 and FGF23 levels between the case group and the control group were compared,and the serum Lp-PLA2,CX3CL1 and FGF23 levels in patients with coronary artery disease with different degrees of disease progression were compared;multifactorial logistic regression was used to analyze the risk factors for the onset of coronary artery disease in patients with coronary artery disease,and the receiver operating characteristic curve(ROC)was used to analyze the value of the serum Lp-PLA2,CX3CL1 and FGF23 levels single and combined tests for the diagnosis of coronary heart disease.Results The proportion of patients with smoking history,combined diabetes and hypertension and serum Lp-PLA2,CX3CL1 and FGF23 levels were higher in the case group than in the control group(P＜0.05).The serum Lp-PLA2,CX3CL1 and FGF23 levels were higher in the severe group than in the moderate and mild groups(P＜0.05);and higher in the moderate group than in the mild group(P＜0.05).The results of multifactorial logistic regression analysis showed that a history of smoking(OR=2.408),combined diabetes mellitus(OR=2.497),combined hypertension(OR=2.221),high serum Lp-PLA2 level(OR=3.083),high serum CX3CL1 level(OR=2.992),and high serum FGF23 level(OR=3.142)were all the risk factors for the development of coronary artery disease(P＜0.05).The results of ROC curve analysis showed that the area under the curve(AUC)value for the diagnosis of coronary artery disease with the combined test of serum Lp-PLA2,CX3CL1,and FGF23 was 0.917,which was higher than that with the single test of the three(0.768,0.807,and 0.872,P＜0.05).Conclusion The serum levels of Lp-PLA2,CX3CL1 and FGF23 were highly expressed in patients with coronary artery disease and all the three could be involved in the process of disease progression in the patients.The combined detection of the three has a higher value for the diagnosis of coronary artery disease.