Relation between body mass index and in-hospital mortality in patients with acute myocardial infarction
WANG Xiu-ling
YIN Chun-lin
XIA Jing-gang
Abstract：Objective To explore the association between body mass index(BMI)and in-hospital mortality in patients with acute myocardial infarction and to evaluate the effect of metabolism and inflammation in the association.Methods The patients with acute myocardial infarction admitted to Xuanwu Hospital of Capital Medical University from January 2017 to December 2022 were included.The clinical data were collected and the logistic regression models were used to evaluate the association between different BMI levels and in-hospital mortality.The metabolic and inflammatory factors were further included to evaluate their mediating effects.Results Among 2928 patients,there were 2289 males and 639 females respevtively;the average age was(63.2±12.5)years.After adjusting for the age,gender,smoking status,previous myocardial infarction,type of myocardial infarction,reperfusion therapy,eGFR,number of stenotic coronary arteries,peak cardiac troponin Ⅰ and left ventricular ejection fraction(LVEF),the obese patients had significantly higher in-hospital mortality risk than normal-weight patients(OR=3.54,95％CI 1.30-9.63,P=0.013)but there was no significant difference in in-hospital mortality risk between the overweight patients and normal-weight patients.After further adjustment for metabolic factors,the result was consistent with the prior result.But after further adjustment for high-sensitivity C-reactive protein,there was no significant difference in in-hospital mortality risk between the obese patients and normal-weight patients.Conclusion Obese patients had a higher risk of in-hospital mortality than normal weight patients.Therefore,more attention should be paid to the management of obese patients with acute myocardial infarction.The effect of anti-inflammatory treatment on acute myocardial infarction patients with different BMI levels needs further research.
Keywords：Body mass indexAcute myocardial infarctionIn-hospital mortalityInflammationMetabolism
Publication Date：2024-06-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 560-564 )