Mild cognitive impairment in atrial fibrillation patients at different CHA2DS2-VASc-60 scores

WANG Xue-ying; LIU Xiao-xia; LAI Jie; WANG Jia

doi:10.3969/j.issn.1672-5301.2024.06.010

Abstract：Objective To investigate the present situation of mild cognitive impairment in atrial fibrillation patients at different CHA2DS2-VASc-60 scores.Methods A total of 125 atrial fibrillation patients admitted to The Emergency General Hospital from October 2022 to June 2023 were assessed for stroke,completed the evaluation of the five neuropsychological scales of cognitive domain including memory,attention,language,execution and visual space function as well as risk factors based on CHA2DS2-VASc-60 score.They were divided into the high stroke risk group,moderate stroke risk group and low stroke risk group.The baseline characteristics and the present situation of mild cognitive impairment in the patients were analyzed.Results There were 25 cases in the low stroke risk group,and the average age was(60.2±3.9)years;there were 39 cases in the moderate stroke risk group,and the average age was(61.6±5.7)years;there were 61 cases in the high stroke risk group,and the average age was 66.9±5.8 years.Among the patients there were no statistical significance in age,education level,the AF duration,hemoglobin,liver and kidney function,blood lipid levels,electrolyte levels,thyroid function,homocysteine levels and D-dimer(P＞0.05).14 patients(56％)had mild cognitive impairment in the low-risk stroke group;18 patients(46.2％)had mild cognitive impairment in the moderate-risk stroke group;38 people existed mild cognitive impairment in the high risk stroke group(62.3％).There were no significant difference among the three groups(F=2.516,P=0.284),but there was a significant difference in the short-term memory between the low-risk group and the other two groups(P＜0.05).Conclusion The prevalence of mild cognitive impairment in AF patients is higher.Patients with a high risk of stroke are more prone to short-term memory decline.Effective anticoagulation may reduce the risk of cognitive decline.