Effects of left bundle branch pacing on cardiac function,plasma BNP level and incidence of arrhythmia in patients with ventricular pacing

HU Qin; HAN Wei-wei; LIANG Jie; ZHOU Feng; JI Cheng; LIU Jin-bo

doi:10.3969/j.issn.1672-5301.2024.06.009

Abstract：Objective To explore the effects of left bundle branch regional pacing(LBBP)on cardiac function,plasma B-type brain natriuretic peptide(BNP)level and arrhythmia incidence in patients with ventricular pacing.Methods 62 patients requiring ventricular pacing admtted to Shijiazhuang People's Hospital from May 2021 to May 2023 were included,and were divided into the LBBP group(32 cases)and the right ventricular septal section pacing(RVSP)group(30 cases)according to the implantation sites of cardiac pacing electrodes.The cardiac function[left ventricular ejection fraction(LVEF),left atrial volume index(LAVI),tricuspid annular displacement during systole(TAPSE),early peak diastolic flow rate at the mitral annulus(E peak),E/Ea],pacing parameters and QRS wave time frame,plasma BNP and 6-minute walk test(6-MWT)and the incidence of arrhythmia were compared between the two groups.Results LVEF and TAPSE were lower in the RVSP group compared with the preoperation and the LBBP group at 6 months postoperatively(P＜0.05);LAVI and E/Ea were higher in the RVSP group compared with the preoperation and the LBBP group at 6 months postoperatively(P＜0.05).There was no significant difference in the comparison of pacing parameters(threshold,perception,impedance)between 2 groups at 1 week,1 month and 6 months postoperatively(P＞0.05).The QRS wave time limits were lower in the LBBP group than in the RVSP group at 1 week,1 month and 6 months postoperatively(P＜0.05).The difference in the incidence of postoperative arrhythmia between the two groups was not significant(P＞0.05).Conclusion Compared with RVSP,LBBP applying to patients with ventricular pacing can effectively reduce the postoperative plasma BNP level and QRS wave time limit,which contributes to the improvement of cardiac function.