Predictive value of detection of serum fibroblast growth factor 21 and fatty acid binding protein 4 for heart failure after percutaneous coronary intervention in patients with acute ST segment elevation myocardial infarction
BAO Mei-zhen
HAN Hui
Abstract：Objective To explore the predictive value of detection of serum fibroblast growth factor 21(FGF21)and fatty acid binding protein 4(FABP4)for heart failure after percutaneous coronary intervention(PCI)in patients with acute ST segment elevation myocardial infarction(STEMI).Methods From September 2020 to September 2022,113 STEMI patients admitted into our hospital were collected as subjects.The patients were separated into the heart failure group(n=32)and the non heart failure group(n=81)according to whether heart failure occurred one year after PCI.ELISA method was applied to measure the expression levels of serum FGF21 and FABP4;the serum levels of FGF21 and FABP4 were compared between the two groups.Multivariate logistic regression was applied to analyze the related factors affected the heart failure in STEMI patients after PCI.ROC curve was applied to evaluate the predictive value of serum FGF21 and FABP4 levels for the heart failure in STEMI patients after PCI.Results The heart rate,C-reactive protein(CRP),cardiac troponin(cTnI),B-type natriuretic peptide precursor(BNP)and the proportion of using diuretics in the heart failure group were obviously higher than those in the non heart failure group,and the left ventricular ejection fraction(LVEF)was obviously lower than that in the non heart failure group(P<0.05).Serum FGF21 and FABP4 expression levels in the heart failure group were significantly higher than those in the non-heart failure group[(228.37±33.07)ng/L vs.(185.68±25.52)ng/L,(34.26±5.51)ng/ml vs.(26.87±4.67)ng/ml,t=7.345,7.195,P<0.05].Serum FGF21(95%CI 1.371-8.191),FABP4(95%CI 1.371-8.191)and time from onset to passage of the guide wire(95%CI 1.058-8.157)were the risk factors for heart failure in STEMI patients after PCI(OR>1,P<0.05),while LVEF(95%CI 0.473-0.913)was the protective factor(OR<1,P<0.05).The area under the curve(AUC)of serum FGF21,FABP4 and their combination in predicting heart failure after PCI in STEMI patients was 0.828,0.856,and 0.934,respectively;the joint prediction of the two is better than a single prediction(Zcombination-FGF21=1.971,Zcombination-FABP4=2.417,P=0.048,P=0.015).Conclusion The serum levels of FGF21 and FABP4 in STEMI patients with heart failure after PCI are obviously elevated;and the combination of the two has higher predictive value for the risk of heart failure in STEMI patients after PCI.
Keywords：Heart failureFibroblast growth factor 21Fatty acid binding protein 4Acute ST segment elevation myocardial infarction
Publication Date：2024-05-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 469-474 )