Clinical application of sacubitril valsartan in the treatment of heart failure
WANG Tian-yun
LI Peng-jin
SHEN Hao-ran
GU Yi-chun
MAO Lu
CHEN Ai-dong
Abstract：Sacubitril valsartan has the anti-fibrotic,reducing myocardial hypertrophy and cell apoptosis effects.It is a drug that can significantly reduce the mortality,hospitalization and readmission rates in patients with heart failure(HF).Only a small proportion of patients in our country have received the treatment with sacubitril valsartan now,and the main obstacle to the clinical application of this drug may be doctors'insufficient understanding of its mechanism,safety and clinical advantages,as well as their obsession with traditional enalapril treatment.This article systematically reviews the proven benefits of sacubitril valsartan in the treatment of HF,aiming to provide clinical guidance and key theoretical basis for its treatment of HF,and to become an important treatment reference for clinical doctors.
Keywords：Sacubitril valsartanHeart failureClinical guidanceTheoretical basis
Publication Date：2024-05-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 410-414 )