Study on the predictive value of serological indexes combined with echocardiographic parameters in atrial septal defect combined with pulmonary hypertension

Maierhaba XUERETI; Wulaer ADELI; TANG Yong-qi; Atikaimu WUBULI; Dilinuer MAIMAITIYIMING

doi:10.3969/j.issn.1672-5301.2024.04.004

Abstract：Objective To the predictive value and clinical significance of serological indexes combined with echocardiographic parameters for atrial septal defect(ASD)merging pulmonary artery hypertension(PAH).Methods A total of 293 patients with ASD diagnosed by color Doppler echocardiography in the First Affiliated Hospital of Xinjiang Medical University from January 2021 to January 2023 were selected.According to whether the patients were complicated by PAH,they were divided into the group without PAH(n=176 cases)and group with PAH(n=1 17 cases).The general clinical data,serological indicators and echocardiographic parameters of the two groups were analyzed.Binary logistic regression analysis was used to obtain the independent risk factors for ASD mergeing PAH.The area under the receiver operating characteristic curve(ROC curve)was used to assess the predictive value that serological indexes and echocardiographic parameters alone and in combination detection for ASD mergeing PAH.Results There were statistically significant differences in the body mass index(BMI),hematocrit(HCT),red blood cell distribution width,N-terminal pro-brain natriuretic peptide(NT-proBNP),uric acid,uric acid/creatinine ratio,albumin,defect diameter,internal diameter of the left atrium,right ventricular outflow tract inner diameter,internal diameter of the right atrium,right ventricular internal dimension,tricuspid valve reflux pressure difference and pulmonary artery systolic pressure between the 2 groups(all P＜0.05).Multifactorial binary logistic regression analysis showed that HCT,red blood cell distribution width,uric acid/creatinine ratio and tricuspid valve reflux pressure difference were the independent risk factors for the ASD mergeing PAH.The area under ROC curve of HCT,red blood cell distribution width,uric acid/creatinine ratio,tricuspid valve reflux pressure difference and combined detection were 0.604,0.584,0.592,0.633 and 0.715,respectively.Conclusion Serological indexes HCT,red cell distribution width,uric acid/creatinine ratio and the echocardiographic parameters tricuspid reflux pressure difference alone and combined detection are of certain value for the prediction of ASD mergeing PAH,but the combined detection has better prediction effect.