Evaluation of the correlation and clinical significance of Chemerin,galectin-3 and visfatin levels with postoperative recurrence in patients undergoing first radiofrequency catheter ablation of atrial fibrillation

ZHOU Tao; GONG Ping; XU Min; WANG Zhi-qin; LI Shuang-fei; ZHANG Da-yong

doi:10.3969/j.issn.1672-5301.2024.03.013

Abstract：Objective To investigate the correlation and clinical significance of Chemerin,galectin-3(Gal-3)and visfatin levels with postoperative recurrence in patients undergoing first radiofrequency catheter ablation for atrial fibrillation(AF).Methods A total of 105 patients with atrial fibrillation who underwent radiofrequency catheter ablation for the first time in Forty Four Hospital of Mianyang,Sichuan Province from September 2021 to August 2023 were selected for prospective cohort study,and were divided into relapse group and non-recurrence group according to whether there was recurrence or not.Baseline data,preoperative Chemerin,Gal-3 and visfatin levels were compared between the two groups.Logistic regression was used to analyze the early warning factors for recurrence,and variance inflation factor and tolerance were used to evaluate whether there was multicollinearity in logistic regression analysis.Receiver operating characteristic curve(ROC)was used to analyze the predictive value of each related factor to recurrence,and the recall rate and accuracy of the combined prediction scheme were evaluated with the precision recall(PR)curve.Results The proportion of OSAS patients in the relapsed group(27.59%)was higher than that in the non-relapsed group(3.95%),and the proportion of ganglion plexus ablation patients(37.93%)was lower than that in the non-relapsed group(61.84%)(P<0.05).The levels of Chemerin,Gal-3 and visfatin in relapsed group were higher than those in non-relapsed group[(170.54±36.83)ng/ml vs.(122.69±31.50)ng/ml、(6.13±2.00)μg/L vs.(3.99±1.25)μg/L、(34.17±10.22)g/ml vs.(21.58±6.97)g/ml,all P<0.05];Logistic regression showed that OSAS,Chemerin,Gal-3 and visfatin were all related risk factors for recurrence,and ganglion plexus ablation was related protective factor for recurrence(P<0.05).Multicollinearity test showed that the variance inflation factor of all related factors ranged from 1.045 to 2.007.The tolerance ranges from 0.544 to 0.901,and the possibility of multicollinearity is low.The original data of OSAS,radial ganglion plexus ablation,Chemerin,Gal-3 and visfatin were randomly divided into test set,verification set and training set according to 20%,20%and 60%,and the ROC curve of OSAS,radial ganglion plexus ablation,Chemerin and Gal-3 combined with visfatin was obtained.The combined AUC of all related factors was 0.911,which was higher than that of OSAS(0.842),ganglion us ablation(0.501),Chemerin(0.780),Gal-3(0.841)and visfatin(0.727)(P<0.05).The PR curve shows that the AUC of the combined scheme of all related factors is 0.858,which has a high recall rate and accuracy rate.Conclusion Preoperative Chemerin,Gal-3 and visfatin levels are closely related to postoperative recurrence in patients with first catheter radiofrency ablation of atrial fibrillation.The combination of the three levels with OSAS and ganglion us ablation shows high predictive performance in predicting recurrence,which can provide objective data reference for clinical identification of high-risk patients with atrial fibrillation recurrence and help develop preventive strategies,reduce postoperative recurrence.