Correlation of remnant cholesterol with cardiovascular outcomes in patients with acute coronary syndromes:a retrospective study

CAO Zi-chen; MENG Fan-hua; ZHOU Ya-qi; FU Zhen-yan

doi:10.3969/j.issn.1672-5301.2024.03.011

Abstract：Objective To investigate the effect of remnant cholesterol(RC)on the long-term prognosis of patients with acute coronary syndromes.Methods Inclusion of 1,943 patients with acute coronary syndromes who underwent percutaneous coronary intervention(PCI)at the Heart Centre of the First Affiliated Hospital of Xinjiang Medical University from January 2017 to January 2021,and the patients were divided into the low level of RC group(≤0.28 mmol/L,n=553),the medium level of RC group(0.28～0.54 mmol/L,n=563)and high RC group(≥0.54 mmol/L,n=560).The primary endpoint was major adverse cardiovascular and cerebrovascular events(MACCE),including all-cause death,myocardial infarction,stroke and unplanned haemodialysis.Results After a median follow-up time of 67(60,73)months,a total of 193 patients developed MACCE events,of which 62 were in the low-level group,72 in the intermediate-level group,and 59 in the high-level group,and there were no significant differences between patients in the intermediate-level group of RC(12.8%vs.11.2%,HR=1.152,95%CI 0.817-1.622)and the high-level group of RC(10.5%vs.11.2%,HR=0.957,95%CI 0.667-1.374).There was no statistically significant difference in the incidence of MACCE in patients in the low RC group(10.5%vs.11.2%,HR=0.957,95%CI 0.667-1.374)compared with the low RC group(P>0.05).Patients in the high-level RC group had a lower mortality rate compared with patients in the low-level RC group(0.2%vs.0.5%;HR=0.336,95%CI 0.035-3.231).However,Cox multifactorial analysis corrected for confounders found that RC level was not an independent predictor of MACCE and death in patients.Conclusions In patients with acute coronary syndromes undergoing PCI,there was no significant correlation between RC levels and the incidence of cardiovascular events in patients.