Progress in research on the anti-apoptotic effects of glucagon-like peptide-1 receptor agonists on cardiomyocytes and related mechanisms
SUN Meng-xin
WANG Li-da
WANG Li-li
LIN Jia-yin
Abstract：Glucagon-like peptide-1(GLP-1)is an endogenous peptide hormone that primarily regulates blood sugar levels by stimulating insulin secretion and inhibiting the release of glucagon.GLP-1 receptor agonists,as a class of innovative synthetic hypoglycemic drugs,can have the same effect as GLP-1,while possessing stronger anti-degradation properties.Current research indicates that GLP-1 receptor agonists can significantly reduce the incidence of cardiovascular events in patients with type 2 diabetes and improve the prognosis of cardiovascular diseases,although their exact mechanisms of action remain to be further clarified.This article reviews the anti-apoptotic effects of GLP-1 receptor agonists on cardiac myocytes and their potential mechanisms,aiming to deepen the understanding of the role of GLP-1 receptor agonists in cardiovascular protection,which is of great significance for optimizing treatment strategies for diabetic patients.
Keywords：Glucagon-like peptide-1 receptor agonistsCardiomyocyteCardiovascular protection
Publication Date：2024-03-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 242-247 )