Correlation between the expression of serum nuclear factor-erythroid 2-related factor 2 and activin A and coronary collateral circulation formation in patients with stable angina pectoris
ZHENG Wan
YANG Shan-shan
YAN Ya-ni
ZHANG Yuan-yuan
Abstract：Objective To investigate the correlation between serum nuclear factor-erythroid 2-related factor 2(NRF2)and activin A expression and coronary collateral circulation formation in patients with stable angina pectoris.Methods From January 2021 to April 2023,80 patients with stable angina who were hospitalized in First Affiliated Hospital of Hainan Medical College,with chronic complete occlusion(CTO)by angiography,were regarded as research subjects and separated into the good group(n=46)and the adverse group(n=34)based on Rentrop classification for collateral circulation formation.ELISA was applied to detect the expression levels of serum NRF2 and activin A;Spearman method was applied to analyze the correlation between serum NRF2 and activin A expression levels and Gensisi score;receiver operating characteristic was applied to analyze the predictive value of serum NRF2 and activin A levels for poor collateral circulation.Results The expression levels of serum NRF2,activin A,and Gensini score in the adverse group were obviously higher than those in the good group[(2.28±0.42)ng/ml vs.(1.46±0.37)ng/ml,(583.67±61.25)pg/ml vs.(472.12±54.26)pg/ml,(45.36±5.81)score vs.(28.49±4.33)score,t=9.251,8.605,14.889,P<0.05];The expression levels of serum NRF2 and activin A were positively correlated with the Gensini score(all P<0.05);the area under the curve(AUC)for predicting poor formation of coronary collateral circulation by combining serum NRF2 and activin A was 0.974,which was superior to the separate diagnosis of serum NRF2 or activin A alone(Z combination-NRF2=2.345,Z combination-activin A=2.639,P= 0.019,P=0.008).Conclusion The expression levels of serum NRF2 and activin A in patients with stable angina pectoris are obviously increased and positively related with the severity of coronary artery stenosis.The combination of the two has higher predictive value for poor formation of coronary collateral circulation in the patients.
Keywords：Nuclear factor-erythroid 2-related factor 2Activin AStable angina pectorisCoronary collateral circulationCorrelation
Publication Date：2024-01-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 79-83 )