Predictive value of nutritional and inflammatory markers for clinical outcomes in patients with infective endocarditis
CHEN Qiao-ming
LIN Zhong-qiu
LI Jia-le
HUANG Yu-mei
GAN Jia-liang
TANG Shuang-yi
Abstract：Objective To explore the predictive value of controlling nutritional status(CONUT)score,neutrophil-to-lymphocyte ratio(NLR)and lymphocyte-to-monocyte ratio(LMR)for clinical outcomes in patients with infective endocarditis.Methods Retrospective analysis was made on the clinical data of 205 patients with infective endocarditis who were hospitalized in First Affiliated Hospital,Guangxi Medical University from July 2012 to December 2022.Multivariate logistic regression analysis was used to determine the risk factors for adverse clinical outcomes in patients with infective endocarditis.The predictive ability of CONUT score,NLR and LMR was tested by the receiver operating characteristic curve(ROC).Results According to the patient's discharge status,78 patients(38%)were assessed as having a poor prognosis.LMR significantly decreased in the group with poor prognosis(P<0.05).Univariate analysis showed that septic shock,atrial fibrillation,intracerebral hemorrhage,staphylococcus infection,and high levels of mean platelet volume,pro-brain natriuretic peptide,NLR,CONUT scores were associated with adverse clinical outcomes of infective endocarditis(P<0.05).Multivariate logistic regression analysis showed that CONUT score,atrial fibrillation and brain natriuretic peptide precursor were the independent predictors of clinical outcomes in patients with infective endocarditis(P<0.05).In the ROC curve analysis,the optimal critical values of CONUT score combined with NLR,CONUT score,NLR and LMR at admission for predicting adverse clinical outcomes in patients with infective endocarditis were 0.318,4.5,5.715 and 1.982,respectively.The area under the curve(AUC)was 0.699,0.684,0.661 and 0.591,respectively.The sensitivity was 0.718,0.654,0.679 and 0.622,respectively,and the specificity was 0.614,0.638,0.685 and 0.590,respectively.Conclusion Compared with NLR and LMR,CONUT score is a more sensitive index to predict the clinical outcome in patients with infective endocarditis,and the combination of CONUT score and NLR can improve the predictive efficiency,providing valuable information for risk stratification and management in patients with infective endocarditis.
Keywords：Infective endocarditisClinical outcomesControlling nutritional status scoreNeutrophil-to-lymphocyte ratioLymphocyte-to-monocyte ratio
Publication Date：2024-01-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 72-78 )