Application of coagulation factor Ⅺ in cardiovascular diseases
WANG Di-kun
ZHANG Li-hui
CHEN Jian-nan
Abstract：Coagulation factor Ⅺ mainly participates in the endogenous coagulation process through contact reaction.However,the study at this stage shows that the role of coagulation factor Ⅺ may be mainly manifested in the growth and expansion of pathological thrombus,and the role in the physiological hemostasis process is relatively small,as a new target for anticoagulant treatment,it will show the same anticoagulant effect and better safety with the currently commonly used anticoagulants.This means that coagulation factor Ⅺ may have a broader prospect in clinical application.In addition,a recent study suggests that inhibiting or reducing F11 gene expression may inhibit myocardial inflammatory response,delay the process of myocardial fibrosis,and further improve the clinical symptoms of ejection fraction preserved heart failure.All these indicate that coagulation factor Ⅺ has potential application value in the treatment of cardiovascular diseases.Although the current research is still in the early stages,coagulation factor Ⅺ,as a new target for the treatment of cardiovascular diseases in the future,deserves further research and exploration.This article analyzes the role of coagulation factor Ⅺ in pathologic thrombosis and physiological hemostasis,emphasizes its potential in anticoagulation therapy,and its potential therapeutic value in myocardial inflammation and fibrosis,and reviews the application of F Ⅺ in cardiovascular diseases.
Keywords：Coagulation factor ⅪF11 geneCardiovascular disease
Publication Date：2024-01-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 36-40 )