Research progress on the regulatory mechanism of deubiquitinase on the TGF-β/Smads pathway
MENG Guo-xin
ZHOU Tao
Abstract：Deubiquitination refers to an important post translational modifications(PTMs)of proteins that remove ubiquitin proteins from the binding complex of protein substrates and ubiquitin molecules,thereby regulating various cellular physiological functions through protein functional changes;TGF-β/Smads pathway can regulate cell proliferation,apoptosis,cell cycle,migration and DNA repair,thereby participating in inflammation,embryonic development,tissue repair and regulating immune function.Literature reports suggest that deubiquitinase can regulate TGF-β/Smads pathway,but the specific mechanism of action is still unclear.This paper summarizes the specific mechanism of the regulation of TGF-β/Smads pathway by different deubiquitinases.
Keywords：DeubiquitinaseTGF-β/Smads pathwayUbiquitin specific proteaseUbiquitin carboxyl terminal hydrolase
Publication Date：2024-01-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 8-13 )