Progress of mitochondrial fusion protein optic atrophy type 1 in cardiovascular diseases
LUO Hao-wen
SUN Lu-xuan
WANG Yu-qi
WANG Xin-yu
CHANG Pan
Abstract：Cardiovascular disease is a serious threat to human health and has become a major cause of death worldwide.In the course of cardiovascular disease research,it has gradually been found that abnormal energy metabolism plays a key role in the occurrence and development of the disease.Mitochondria produces 90%of the ATP in the human body,therefore the stability of mitochondrial function is essential for maintaining normal cellular form and function.Previous studies have found that optic atrophy type 1(OPA1),located on the inner mitochondrial membrane,is essential for the maintenance of mitochondrial function and has a protective effect against cardiovascular-related diseases such as atherosclerosis,ischemia-reperfusion injury,heart failure and diabetic cardiomyopathy.In this review,The paper outlines recent findings regarding OPA1 protein function,dysfunction and associated clinical phenotypes,with a focus on current therapeutic options and future prospects for the treatment of OPA1 mutation-induced related cardiovascular diseases.
Keywords：Optic atrophy type 1Cardiovascular diseaseAtherosclerosisHeart failure
Publication Date：2024-01-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3-7 )