Advances in the application of small molecule nucleic acid drugs in lipid-lowering therapy
YE Jiang-ping
CHEN Liang
ZONG Gang-jun
Abstract：Atherosclerotic cardiovascular disease currently ranks as the leading cause of mortality in the world.The abnormalities in lipids or lipoproteins are the primary reason for atherosclerosis.The efficacy of traditional lipid-lowering drugs such as statins sometimes fails to meet the target,so residual cardiovascular risk needs to be urgently addressed.With the development of molecular biology,many relevant studies have been conducted on small molecule nucleic acid drugs in lipid lowering by virtue of their unique mechanisms and advantages,but the studies on different targets are still at different stages.In this article,The research progress of small molecule nucleic acid drugs in lipid lowering is reviewed.
Keywords：Small Interfering RNAAntisense oligonucleotidesLipid-lowering therapy
Publication Date：2023-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1133-1137 )