Analysis of predictive value of serum platelet activating factor and lipoprotein-associated phospholipase A2 for coronary slow flow phenomenon
SHI Zhi-fang
JIA Ying
ZHANG Xiu-jing
TAN Hua
WANG Ai-min
ZHAO Jie
Abstract：Objective To explore the predictive value of serum platelet activating factor(PAF)and lipoprotein-associated phospholipase A2(Lp-PLA2)for slow coronary flow.Methods A total of 98 patients with slow coronary flow during coronary angiography in Shijiazhuang third Hospital from October 2020 to October 2022 were set as the slow flow group,and another 108 patients with normal coronary flow were set as the normal group.All the subjects were tested for serum PAF and Lp-PLA2 levels.The clinical data and laboratory indexes of the two groups were compared,and a receiver operating curve(ROC)was drawn to analyze the predictive value of serum PAF and Lp-PLA2 levels on slow coronary flow.Results The proportion of hypertension,serum PAFand Lp-PLA2 levels in the slow flow group were higher than those in the normal group[43.88%vs.28.70%,(113.72±43.65)μg/L vs.(76.42±15.63)μg/L,(70.16±26.71)μg/L vs.(41.54±14.68)μg/L,all P<0.05].Logistic regression analysis showed that hypertension(95%CI 1.090-3.458),serum PAF(95%CI 1.018-1.044)and Lp-PLA2(95%CI 1.039-1.082)levels were the risk factors for slow coronary flow(OR>1,P<0.05).In the two-point correlation analysis,both serum PAF and Lp-PLA2 levels positively correlated with slow coronary flow(r=0.503 and 0.560,P<0.05).The ROC curve showed that,the AUCs of serum PAF and Lp-PLA2 levels for the prediction of slow coronary flow were 0.785,0.816,and 0.854,when the cut-off values were 88.880 μg/L and 53.095 μg/L respectively,the best predictive value was obtained,and the AUC of combined detection was 0.854(95%CI 0.798-0.911),the predictive value was higher.Conclusion Both serum PAF and Lp-PLA2 levels are closely related to the slow coronary flow phenomenon,and the slow coronary flow phenomenon can be predicted clinically by detecting their levels.
Keywords：Coronary slow flow phenomenonPlatelet activating factorLipoprotein-associated phospholipase A2
Publication Date：2023-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1080-1085 )