Correlation between neutrophil gelatinase lipid carrier protein and coronary plaque structure in patients with stable angina pectoris

LIU Cheng-feng; YU Wen-ya; XING Kun; YE Chen; YANG Yu-juan

doi:10.3969/j.issn.1672-5301.2023.12.004

Abstract：Objective To explore the correlation between the plasma neutrophil gelatinase lipid carrier protein(NGAL)leveland the structure of coronary atherosclerotic plaque in the patients with stable angina pectoris(SAP).Method 72 patients who were diagnosed with stable angina pectoris in Shanxi Provincial People's Hospital from November 2021 to June 2022were enrolled according to the inclusion and exclusion criteria,The clinical data and laboratory examination data of the patients were collected,as well as the intravascular ultrasound(IVUS)examination of the coronary artery.The correlation of plasma NGAL level with the structural indicators of coronary plaque was analyzed.Results Correlation analysis showed that the plasma NGAL level was inversely proportional to the fiber cap thickness of coronary atherosclerotic plaque within a certain range(r=-0.563,P<0.01)and directly proportional to the plaque burden(r=0.328,P<0.01),which had a significant difference.According to the distribution characteristics of plaque fiber cap thickness data,the people was divided into the thin fiber cap group and the thick fiber cap group in the light of M=0.4583 mm.Logistic regression analysis showed that the NGAL level was the influencing factor of plaque fiber cap thickness(OR=4,95%CI 1.501-10.658,P<0.01).The patients were divided into the low plaque load group and high plaque load group with 70%of coronary atherosclerotic plaque load as the threshold and then.Logistic regression analysis showed that the plasma NGAL level was the influencing factor of coronary atherosclerotic plaque load(OR=7.800,95%CI 2.731-22.274,P<0.01).Conclusion There is a significant correlation between the plasma NGAL level and the coronary atherosclerotic plaque in patients with stable angina pectoris:the NGAL level higher,the fibrous cap of atherosclerotic thinner and the plaque load bigger.The plasma NGAL is the influencing factor of the structural characteristics of coronary atherosclerotic plaque.